The benefits of higher LMR for early threatened abortion: A retrospective cohort study

PLoS One. 2020 Apr 20;15(4):e0231642. doi: 10.1371/journal.pone.0231642. eCollection 2020.

Abstract

Problem: To investigate the relation of inflammation-related parameters and pregnancy outcome in women with the early threatened abortion.

Method of study: 630 women with early threatened abortion were divided into two groups based on the pregnancy outcome. All of them had the blood routine examination before treating. The differences between two groups were analyzed by the Chi-squared test, Student T test, Mann-Whitney U test, Binary Logistic Regression, Marginal Structural Model and Threshold effect analysis.

Results: We found that there is no significant difference in the pregnancy outcome for NLR (OR:0.92, CI95%:0.72, 1.17) and PLR (OR:1.00, CI%:0.99, 1.01). However, a difference had a statistical significance in the pregnancy outcome when LMR less than 2.19 (OR:0.39, CI95%:0.19,0.82).

Conclusions: This study suggested that higher LMR was related to the lower risk of miscarriage in the women with early threatened abortion in a way.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous / blood*
  • Abortion, Spontaneous / prevention & control
  • Adult
  • Female
  • Humans
  • Lymphocyte Count
  • Pregnancy
  • Pregnancy Outcome
  • Retrospective Studies

Grants and funding

National Natural Science Foundation of China (No.81774358); Fok Ying-Tong Education Foundation of China (No.151042); Pearl River Scholars, Department of Education, Guangdong Province (Guangdong teacher's letter[2017]number79); Scientific Research Team Training Project of GZUCM(2019KYTD202); Guangzhou Univ Chinese Med Planning[2019]5 (XK2019016).