Agammaglobulinemia or hypogammaglobulinemia is a rare inherited immunodeficiency disorder. It is characterized by low or absent mature B cells, which can result in severe antibody deficiency and recurrent infections. It can manifest in an infant as soon as the protective effect of maternal immunoglobulins wanes at around six months of age.
Agammaglobulinemia is comprised of the following types:
X-linked agammaglobulinemia (XLA), discovered in 1952 by Dr. Ogden Bruton.
X-linked agammaglobulinemia with growth hormone deficiency
Autosomal recessive agammaglobulinemia (ARAG)
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