Indomethacin

Excerpt

Indomethacin is a non-steroidal anti-inflammatory (NSAID) drug with broad applications. It inhibits the synthesis of prostaglandins produced primarily by cyclooxygenase enzymes which are critical mediators of inflammation, fever, and pain. Indomethacin is FDA-approved to manage acute pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, bursitis, gouty arthritis, and patent ductus arteriosus. This activity reviews the indications, action, and contraindications of indomethacin as a valuable agent. In addition, this activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, and relevant interactions) pertinent to members of the interprofessional healthcare team.