Cardiac FGF23: a new player in myocardial infarction

David Schumacher; Alexander Schuh

doi:10.15190/d.2019.10

Cardiac FGF23: a new player in myocardial infarction

Discoveries (Craiova). 2019 Sep 30;7(3):e97. doi: 10.15190/d.2019.10.

Authors

David Schumacher¹, Alexander Schuh²

Affiliations

¹ Department of Anesthesiology, University Hospital, RWTH Aachen, Germany.
² Department of Cardiology and Pulmonology, Medical Faculty, RWTH Aachen University, Germany.

Abstract

Fibroblast Growth Factor 23 (FGF23) is a hormone involved in phosphate metabolism. It is known that FGF23 is increased in different pathologies including chronic kidney disease, heart failure or X-linked hypophosphatemia and directly correlates with negative outcome and mortality in severe diseases. However, the role of FGF23 in cardiovascular pathologies is still under debate. This review summarizes the current knowledge about the role of FGF23 in ischemic heart diseases, such as myocardial infarction.

Keywords: FGF-23; Fibroblast Growth Factor 23; cardiac hypertrophy.; cytokines; fibrosis; heart failure; inflammation; ischemic heart disease; myocardial infarction.

Publication types

Review