First Report of OXA-181-Producing Klebsiella pneumoniae in China

Congcong Liu; Yinfei Fang; Yu Zeng; Jiayue Lu; Qiaoling Sun; Hongwei Zhou; Zhangqi Shen; Gongxiang Chen

doi:10.2147/IDR.S237793

First Report of OXA-181-Producing Klebsiella pneumoniae in China

Infect Drug Resist. 2020 Apr 6:13:995-998. doi: 10.2147/IDR.S237793. eCollection 2020.

Authors

Congcong Liu¹, Yinfei Fang², Yu Zeng¹, Jiayue Lu¹, Qiaoling Sun¹, Hongwei Zhou¹, Zhangqi Shen³, Gongxiang Chen¹

Affiliations

¹ Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, Hangzhou, People's Republic of China.
² Department of Clinical Laboratory, Jinhua Municipal Central Hospital, Zhejiang, Jinhua, People's Republic of China.
³ Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.

Abstract

We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene bla _OXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K. pneumoniae isolate might have originated from Escherichia coli and have the potential to mediate the spread of bla _OXA-181.

Keywords: China; IncX3 plasmid; Klebsiella pneumoniae; OXA-181; human.