Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV)

Sarah Afaq; Akhtar Atiya; Arshi Malik; Afaf S Alwabli; Dhafer A Alzahrani; Habeeb M Al-Solami; Othman Alzahrani; Qamre Alam; Mohammad Azhar Kamal; Aala A Abulfaraj; Alawiah M Alhebshi; Mohammed Tarique

doi:10.6026/97320630016229

Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV)

Bioinformation. 2020 Mar 31;16(3):229-235. doi: 10.6026/97320630016229. eCollection 2020.

Authors

Affiliations

¹ Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.
² Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.
³ Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
⁴ Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.
⁵ Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
⁶ University of Jeddah, Faculty of Science, Department of Biochemistry, Jeddah, Kingdom of Saudi Arabia.
⁷ University of Jeddah Center for Science and Medical Research (UJC-SMR), Jeddah, Kingdom of Saudi Arabia.
⁸ Department of Biological Sciences, College of Sciences and Arts-Rabigh Campus, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
⁹ Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India.

Abstract

A comprehensive analysis of methyltransferase (MTase) from Zika virus (ZIKV) is of interest in the development of drugs and biomarkers in the combat and care of ZIKA fever with impulsive joint pain and conjunctivitis. MTase sequence is homologous in several viral species. We analyzed the MTase domain from ZIKV using Bioinformatics tools such as SMART, PROSITE, PFAM, PANTHER, and InterProScan to glean insights on the sequence to structure to function data. We document inclusive information on MTase from ZIKV for application in the design of drugs and biomarkers to fight against the disease.

Keywords: Pfam and InterProScan; Prosite; SMART; ZIKV; beta turn; methyltransferase; α-helix.