An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

J Enzyme Inhib Med Chem. 2020 Dec;35(1):1027-1044. doi: 10.1080/14756366.2020.1732366.

Abstract

As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours with fewer side effects. This article describes several FTIs extracted from natural materials and clarifies the current research progress, which provides a new choice for the treatment of tumours.

Keywords: FTIs; Ras protein; Tumour; inhibitors; natural materials.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Farnesyltranstransferase / antagonists & inhibitors*
  • Farnesyltranstransferase / metabolism
  • Humans
  • Molecular Structure
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Biological Products
  • Enzyme Inhibitors
  • Farnesyltranstransferase

Grants and funding

This work was financially supported by Natural Science Foundation of Shandong, China [Grant No. ZR2019MC004]. This work was also financially supported by the high-end talent team construction foundation [Grant No. 108-10000318].