Detection of subclonal SETBP1 and JAK3 mutations in juvenile myelomonocytic leukemia using droplet digital PCR

Leukemia. 2021 Jan;35(1):259-263. doi: 10.1038/s41375-020-0817-x. Epub 2020 Apr 20.

Authors

Manabu Wakamatsu¹, Yusuke Okuno², Norihiro Murakami¹, Shunsuke Miwata¹, Hironobu Kitazawa¹, Kotaro Narita¹, Shinsuke Kataoka¹, Daisuke Ichikawa¹, Motoharu Hamada¹, Rieko Taniguchi¹, Kyogo Suzuki¹, Nozomu Kawashima¹, Eri Nishikawa¹, Atsushi Narita¹, Nobuhiro Nishio^{1

3}, Seiji Kojima¹, Hideki Muramatsu⁴, Yoshiyuki Takahashi⁵

Affiliations

¹ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
² Medical Genomics Center, Nagoya University Hospital, Nagoya, Japan.
³ Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
⁴ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. hideki-muramatsu@med.nagoya-u.ac.jp.
⁵ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. ytakaha@med.nagoya-u.ac.jp.

PMID: 32307441
DOI: 10.1038/s41375-020-0817-x

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor
Carrier Proteins / genetics*
DNA Mutational Analysis / methods
Humans
Janus Kinase 3 / genetics*
Leukemia, Myelomonocytic, Juvenile / diagnosis*
Leukemia, Myelomonocytic, Juvenile / genetics*
Mutation*
Nuclear Proteins / genetics*
Polymerase Chain Reaction* / methods

Substances

Biomarkers, Tumor
Carrier Proteins
Nuclear Proteins
SETBP1 protein, human
JAK3 protein, human
Janus Kinase 3