[A patient with neurosarcoidosis presenting with easy falling and dysphagia]

Rinsho Shinkeigaku. 2020 May 26;60(5):346-350. doi: 10.5692/clinicalneurol.cn-001404. Epub 2020 Apr 18.
[Article in Japanese]

Abstract

A 68-year-old woman was referred to our hospital for progressive dizziness, gait disturbances and weight loss for 18 months. The patient was alert and showed dysphagia and a marked tendency to fall backward. Electronystagmography showed bilateral vestibular dysfunction and audiometry showed right sensorineural hearing disturbance. Cerebrospinal fluid exam showed mononuclear pleocytosis and elevated protein levels. On 18F-FDG PET/CT, abnormal uptake was observed in the mediastinal lymph nodes, from which biopsy specimens were obtained. Histological findings showed non-caseous granuloma and a diagnosis of bilateral vestibulocochlear, glossopharyngeal and vagal nerve palsies due to neurosarcoidosis was made. Steroid therapy resulted in improvement in her clinical symptoms. Neurosarcoidosis should be included in the differential diagnosis of patients showing progressive easy falling and dysphagia.

Keywords: bilateral vestibulopathy; dysphagia; easy falling; neurosarcoidosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Accidental Falls*
  • Aged
  • Central Nervous System Diseases / complications*
  • Central Nervous System Diseases / diagnosis*
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / pathology
  • Deglutition Disorders / etiology*
  • Diagnosis, Differential
  • Female
  • Frailty / etiology*
  • Humans
  • Leukocytosis / etiology
  • Positron Emission Tomography Computed Tomography
  • Prednisolone / administration & dosage
  • Sarcoidosis / complications*
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / drug therapy
  • Sarcoidosis / pathology
  • Treatment Outcome

Substances

  • Prednisolone

Supplementary concepts

  • Neurosarcoidosis