ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime

Linda Quatrini; Lorenzo Moretta; Maria Cristina Mingari

doi:10.1016/j.it.2020.03.011

ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime

Trends Immunol. 2020 May;41(5):364-366. doi: 10.1016/j.it.2020.03.011. Epub 2020 Apr 16.

Authors

Linda Quatrini¹, Lorenzo Moretta¹, Maria Cristina Mingari²

Affiliations

¹ Department of Immunology, IRCSS Bambino Gesù Children's Hospital, 00146 Rome, Italy.
² Department of Experimental Medicine (DIMES) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy; UOC Immunology Unit IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. Electronic address: mariacristina.mingari@unige.it.

PMID: 32307240
DOI: 10.1016/j.it.2020.03.011

Abstract

Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal immunity by inducing ILC3s to produce protective IL-22.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gastrointestinal Microbiome*
Humans
Immunity, Mucosal
Intestinal Mucosa
Neuropeptides*
Permeability

Substances

Neuropeptides