Receptor-Binding Assays of Enterovirus D68

Tadatsugu Imamura; Michiko Okamoto; Hitoshi Oshitani

doi:10.1007/978-1-0716-0430-4_54

Receptor-Binding Assays of Enterovirus D68

Methods Mol Biol. 2020:2132:629-639. doi: 10.1007/978-1-0716-0430-4_54.

Authors

Tadatsugu Imamura¹, Michiko Okamoto², Hitoshi Oshitani²

Affiliations

¹ Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan. imamura-t@ncchd.go.jp.
² Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

PMID: 32306362
DOI: 10.1007/978-1-0716-0430-4_54

Abstract

Human enterovirus D68 (EV-D68) is a causative agent for acute respiratory infections and potentially central nervous system illnesses with increasing epidemiological significance. Recent studies have highlighted the role of sialic acids as a functional receptor for EV-D68 in vitro. However, further investigations are required to reveal its significance in actual infections in human.

Keywords: Acute flaccid paralysis; Enterovirus D68; Picornaviruses; Respiratory tract infections; Sialic acids.

MeSH terms

Animals
Cell Adhesion Molecules / chemistry*
Cell Adhesion Molecules / metabolism
Cell Line
Enterovirus D, Human / physiology*
Enterovirus Infections / metabolism
Enterovirus Infections / virology
Guinea Pigs
Humans
Nerve Tissue Proteins / chemistry*
Nerve Tissue Proteins / metabolism
Neurons / cytology
Neurons / metabolism
Neurons / virology*
Sialic Acids / metabolism*
Virus Attachment
Virus Internalization

Substances

Cell Adhesion Molecules
ICAM5 protein, human
Nerve Tissue Proteins
Sialic Acids