Alkaloids, especially heterocyclic alkaloids, have received remarkable attention due to their intriguing structures and potential pharmacological activities. The marine fungi residing in extreme environmental conditions are among the richest sources of these basic nitrogen-containing compounds. Fungal species belonging to the genus Penicillium have been studied worldwide for their biosynthetic potential for generating bioactive alkaloids. This paper offers a systematic review of the newly reported alkaloids produced by marine-derived Penicillium species over the past five years (covering the literature from the beginning of 2014 through the end of 2018) and describes the structural diversity, biological activities, and plausible biosynthetic pathway of the reported compounds. A total of 106 alkaloids and 81 references are included in this review, which is expected to be beneficial for drug development and biosynthesis in the near future.
Keywords: Alkaloid; Biological activity; Biosynthesis; Marine fungus; Penicillium.
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