Retinal Toxicity in a Patient on Pentosan Polysulfate Sodium

Maxwell J Wingelaar; Joseph J Raevis; Karina A Conlin; Kimberly E Stepien

doi:10.1016/j.urology.2020.04.006

Retinal Toxicity in a Patient on Pentosan Polysulfate Sodium

Urology. 2020 Jul:141:e41-e42. doi: 10.1016/j.urology.2020.04.006. Epub 2020 Apr 17.

Authors

Maxwell J Wingelaar¹, Joseph J Raevis², Karina A Conlin², Kimberly E Stepien²

Affiliations

¹ University of Wisconsin-Madison, Department of Ophthalmology, Madison, WI. Electronic address: wingelaarm@gmail.com.
² University of Wisconsin-Madison, Department of Ophthalmology, Madison, WI.

PMID: 32305545
DOI: 10.1016/j.urology.2020.04.006

Abstract

Pentosan Polysulfate Sodium (PPS) is commonly used in the treatment of interstitial cystitis/bladder pain syndrome. Recently there have been reported cases of retinal toxicity associated with long-term PPS use. We present a case of a 42-year-old female taking PPS for the last 10 years who was found to have signs of retinal toxicity, but was completely asymptomatic. PPS was discontinued after these retinal findings were discovered.

Publication types

Case Reports

MeSH terms

Adult
Cystitis, Interstitial / drug therapy
Female
Humans
Pentosan Sulfuric Polyester / adverse effects*
Pentosan Sulfuric Polyester / therapeutic use
Retinal Diseases / chemically induced*

Substances

Pentosan Sulfuric Polyester