Structure-Mediated Degradation of CircRNAs

Yingli Guo; Xiawei Wei; Yong Peng

doi:10.1016/j.tcb.2020.04.001

Structure-Mediated Degradation of CircRNAs

Trends Cell Biol. 2020 Jul;30(7):501-503. doi: 10.1016/j.tcb.2020.04.001. Epub 2020 Apr 15.

Authors

Yingli Guo¹, Xiawei Wei², Yong Peng³

Affiliations

¹ Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
² Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Electronic address: xiaweiwei@scu.edu.cn.
³ Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Electronic address: yongpeng@scu.edu.cn.

PMID: 32305233
DOI: 10.1016/j.tcb.2020.04.001

Abstract

The elaborate control of biogenesis and turnover is essential for circular RNAs (circRNAs) to exert their functions properly in eukaryotic cells, whereas how circRNAs are degraded remains unclear. A recent study by Fischer et al. reveals a novel structure-mediated circRNA decay that selectively degrades highly structured RNAs by UPF1 and G3BP1.

Keywords: G3BP1; UPF1; circular RNA; degradation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Models, Biological
Poly A / metabolism
RNA Stability / genetics*
RNA, Circular / chemistry*

Substances

RNA, Circular
Poly A