Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis

Luc Rochette; Alexandre Méloux; Marianne Zeller; Yves Cottin; Catherine Vergely

doi:10.1016/j.bbadis.2020.165798

Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis

Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;1866(8):165798. doi: 10.1016/j.bbadis.2020.165798. Epub 2020 Apr 15.

Authors

Luc Rochette¹, Alexandre Méloux², Marianne Zeller², Yves Cottin³, Catherine Vergely²

Affiliations

¹ Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases research team (PEC2, EA 7460), University of Bourgogne - Franche-Comté, Faculty of Health Sciences, 7 boulevard Jeanne d'Arc, 21079 Dijon, France. Electronic address: luc.rochette@u-bourgogne.fr.
² Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases research team (PEC2, EA 7460), University of Bourgogne - Franche-Comté, Faculty of Health Sciences, 7 boulevard Jeanne d'Arc, 21079 Dijon, France.
³ Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases research team (PEC2, EA 7460), University of Bourgogne - Franche-Comté, Faculty of Health Sciences, 7 boulevard Jeanne d'Arc, 21079 Dijon, France; Cardiology Unit, Dijon University Hospital, Dijon, France.

PMID: 32304740
DOI: 10.1016/j.bbadis.2020.165798

Abstract

Obesity and related metabolic dysregulation are risk factors for many types of cancer. The interactions between a developing tumor and its microenvironment are known to implicate a complex "crosstalk" among the factors produced by the population of cells. Among these factors, Growth and differentiation factor 15 (GDF15) has a functional role in cancer. GDF15 expression is induced in response to the conditions associated with cellular stress and diseases. The GDF15 receptor, a member of the glial-cell-derived neurotropic factor family (GDNF), is a GDNF family receptor α-like (GFRAL) protein. GDF15 induces pro-angiogenic effects in tumors. However, GDF15 could affect tumorigenesis both positively and negatively. With a better understanding of the upstream disease pathways reflected by GDF15, new treatment targets may emerge.

Keywords: Angiogenesis; Cancer; GDF15; Obesity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinogenesis / genetics*
Carcinogenesis / metabolism
Carcinogenesis / pathology
Cyclic AMP Response Element-Binding Protein / genetics
Cyclic AMP Response Element-Binding Protein / metabolism
Gene Expression Regulation, Neoplastic*
Growth Differentiation Factor 15 / genetics*
Growth Differentiation Factor 15 / metabolism
Humans
Inflammation
NF-kappa B / genetics
NF-kappa B / metabolism
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology
Neovascularization, Pathologic / genetics*
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / pathology
Obesity / genetics*
Obesity / metabolism
Obesity / pathology
Signal Transduction
Smad Proteins / genetics
Smad Proteins / metabolism
Tumor Microenvironment / genetics*

Substances

CREB1 protein, human
Cyclic AMP Response Element-Binding Protein
GDF15 protein, human
Growth Differentiation Factor 15
NF-kappa B
Smad Proteins