Targeting ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Cancer

Lixia Gao; Jenni Loveless; Chloe Shay; Yong Teng

doi:10.1007/978-3-030-42667-5_1

Targeting ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Cancer

Adv Exp Med Biol. 2020:1260:1-12. doi: 10.1007/978-3-030-42667-5_1.

Authors

Lixia Gao¹, Jenni Loveless², Chloe Shay³, Yong Teng^{4

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Affiliations

¹ International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, Chongqing, P. R. China.
² Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
³ Department of Pediatrics, Emory Children's Center, Emory University, Atlanta, GA, USA.
⁴ Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA. yteng@augusta.edu.
⁵ Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA. yteng@augusta.edu.
⁶ Department of Medical Laboratory, Imaging and Radiologic Sciences, College of Allied Health, Augusta University, Augusta, GA, USA. yteng@augusta.edu.

PMID: 32304028
DOI: 10.1007/978-3-030-42667-5_1

Abstract

The control of crosstalk between autophagy and apoptosis in tumor cells can remove a critical barrier to comprehensive and efficacious treatment for cancer. Reactive oxygen species (ROS), by-products of redox homeostasis, are critical for regulating the balance between autophagy and apoptosis in cancer cells upon different drug treatments and gene modifications. The mechanisms and consequences involved in ROS-mediated crosstalk between apoptosis and autophagy are extremely complex in cancer cells. Here, we mainly discuss the closely linked relationship between ROS levels, autophagy, and apoptosis in cancer therapy.

Keywords: Anticancer strategy; Apoptosis; Autophagy; Cancer; ROS; Reactive oxygen species.

Publication types

Review

MeSH terms

Apoptosis*
Autophagy*
Humans
Neoplasms / metabolism*
Oxidation-Reduction
Reactive Oxygen Species / metabolism*

Substances

Reactive Oxygen Species