A case of Henoch-Schönlein purpura associated with scrub typhus

BMC Infect Dis. 2020 Apr 17;20(1):286. doi: 10.1186/s12879-020-05001-x.

Abstract

Background: Henoch-Schönlein purpura (HSP) may be caused by several allergens. However, to date, HSP caused by Orientia tsutsugamushi has not been reported. Here, we report an unusual rash with features of HSP caused by Orientia tsutsugamushi.

Case presentation: A man visited a tertiary hospital with bilateral symmetrical purpura and fever. He presented with an eschar in the left popliteal fossa and proteinuria. He was diagnosed with tsutsugamushi disease by indirect fluorescent antibody and positive polymerase chain reaction tests. Purpura biopsy demonstrated a feature of leukocytoclastic vasculitis and IgA deposition in dermal vessels, indicative of HSP.

Conclusions: When examining patients with unique rashes, such as in this case, we suggest investigating out-door activities and evidence of mite bites. Furthermore, differential diagnosis of tsutsugamushi disease should be considered when necessary.

Keywords: Case report; Cutaneous, Leukocytoclastic; Henoch-Schönlein; Orientia tsutsugamushi; Scrub typhus.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Biopsy
  • Diagnosis, Differential
  • Humans
  • IgA Vasculitis / diagnosis*
  • IgA Vasculitis / drug therapy
  • IgA Vasculitis / microbiology
  • IgA Vasculitis / pathology
  • Male
  • Middle Aged
  • Orientia tsutsugamushi / genetics
  • Orientia tsutsugamushi / immunology
  • Orientia tsutsugamushi / isolation & purification*
  • Scrub Typhus / diagnosis*
  • Scrub Typhus / drug therapy
  • Scrub Typhus / microbiology
  • Scrub Typhus / pathology
  • Skin / pathology
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents