Omega polyunsaturated fatty acids and parasitic infections: An overview

Acta Trop. 2020 Jul:207:105466. doi: 10.1016/j.actatropica.2020.105466. Epub 2020 Apr 14.

Abstract

Omega-3 and omega-6 polyunsaturated fatty acids are synthesized from the essential fatty acids alpha-linolenic acid and linoleic acid, respectively. They are pivotal components of all mammalian cells and were found to be useful in prevention and treatment of a variety of health problems owing to their anti-inflammatory and anti-microbial properties. Omega-3 and omega-6 polyunsaturated fatty acids are further metabolized to anti-inflammatory mediators, such as lipoxins, resolvins, and protectins. Moreover, these polyunsaturated fatty acids were found to have in vivo and in vitro protective efficacies against some parasitic infections. Therefore, dietary intake of polyunsaturated fatty acids should be encouraged because of their considerable beneficial effects.

Keywords: Alpha-linolenic acid; Fish oil; Linoleic acid; Parasites; Polyunsaturated fatty acids.

Publication types

  • Review

MeSH terms

  • Fatty Acids, Omega-3 / administration & dosage*
  • Fatty Acids, Omega-3 / pharmacology
  • Fatty Acids, Omega-6 / administration & dosage*
  • Fatty Acids, Omega-6 / pharmacology
  • Fatty Acids, Unsaturated / classification
  • Humans
  • Parasitic Diseases / prevention & control*

Substances

  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6
  • Fatty Acids, Unsaturated