Just Took a DNA Test, Turns Out 100% Not That Phase

Aaron D Gitler; James Shorter; Taekjip Ha; Sua Myong

doi:10.1016/j.molcel.2020.03.029

Just Took a DNA Test, Turns Out 100% Not That Phase

Mol Cell. 2020 Apr 16;78(2):193-194. doi: 10.1016/j.molcel.2020.03.029.

Authors

Aaron D Gitler¹, James Shorter², Taekjip Ha³, Sua Myong⁴

Affiliations

¹ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
² Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jshorter@pennmedicine.upenn.edu.
³ Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: tjha@jhu.edu.
⁴ Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: smyong1@jhu.edu.

PMID: 32302539
DOI: 10.1016/j.molcel.2020.03.029

Abstract

Heterochromatin protein 1 (HP1) has been proposed to drive heterochromatin formation by liquid-liquid phase separation. In this issue of Molecular Cell, however, Erdel et al. establish that heterochromatin can adopt digital compaction states that are independent of HP1 phase separation.

Publication types

Comment

MeSH terms

Animals
Chromatin Assembly and Disassembly
Chromobox Protein Homolog 5
Chromosomal Proteins, Non-Histone*
DNA
Heterochromatin*
Mice

Substances

Chromosomal Proteins, Non-Histone
Heterochromatin
Chromobox Protein Homolog 5
DNA

Grants and funding

S10 OD021567/OD/NIH HHS/United States