Abstract
MRI with hyperpolarized 129Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as a 129Xe MRI contrast agent with a moderate exchange rate, sufficient stability and feasible surface modification. The αvβ3 integrin overexpressed by non-small-cell lung cancer A549 cells was successfully detected by 129Xe MRI with high specificity through adequate surface modifications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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A549 Cells
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Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
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Carcinoma, Non-Small-Cell Lung / genetics
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Fluorocarbons / chemistry*
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Humans
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Hydrocarbons, Brominated / chemistry*
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Integrin alphaVbeta3 / genetics
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Lung Neoplasms / diagnostic imaging*
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Lung Neoplasms / genetics
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Magnetic Resonance Imaging*
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Nanoparticles / chemistry*
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Particle Size
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Silicon Dioxide / chemistry*
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Surface Properties
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Xenon Isotopes
Substances
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Fluorocarbons
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Hydrocarbons, Brominated
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Integrin alphaVbeta3
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Xenon Isotopes
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Silicon Dioxide
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perflubron