Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

J Mater Chem B. 2020 Jun 21;8(23):5014-5018. doi: 10.1039/d0tb00484g. Epub 2020 Apr 17.

Abstract

MRI with hyperpolarized 129Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as a 129Xe MRI contrast agent with a moderate exchange rate, sufficient stability and feasible surface modification. The αvβ3 integrin overexpressed by non-small-cell lung cancer A549 cells was successfully detected by 129Xe MRI with high specificity through adequate surface modifications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Fluorocarbons / chemistry*
  • Humans
  • Hydrocarbons, Brominated / chemistry*
  • Integrin alphaVbeta3 / genetics
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / genetics
  • Magnetic Resonance Imaging*
  • Nanoparticles / chemistry*
  • Particle Size
  • Silicon Dioxide / chemistry*
  • Surface Properties
  • Xenon Isotopes

Substances

  • Fluorocarbons
  • Hydrocarbons, Brominated
  • Integrin alphaVbeta3
  • Xenon Isotopes
  • Silicon Dioxide
  • perflubron