Advances in Diagnostic Procedures and Their Applications in the Era of Cancer Immunotherapy

Mingxuan Xu; Ilgin Ergin; Semir Beyaz

doi:10.1007/978-3-030-41008-7_2

Advances in Diagnostic Procedures and Their Applications in the Era of Cancer Immunotherapy

Adv Exp Med Biol. 2020:1244:37-50. doi: 10.1007/978-3-030-41008-7_2.

Authors

Mingxuan Xu¹, Ilgin Ergin², Semir Beyaz²

Affiliations

¹ Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mxu2@mdanderson.org.
² Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.

PMID: 32301009
DOI: 10.1007/978-3-030-41008-7_2

Abstract

Diagnostic procedures play critical roles in cancer immunotherapy. In this chapter, we briefly discuss three major diagnostic procedures widely used in immunotherapy: immunohistochemistry, next-generation sequencing, and flow cytometry. We also describe the uses of other diagnostic procedures and preclinical animal models in cancer immunotherapy translational research.

Keywords: Biomarker; Diagnostic procedure; Flow cytometry; Genetic diagnostics; Immunohistochemistry; Immunotherapy; Microarray; Next-generation sequencing; Polymerase chain reaction; Preclinical animal models; Proteomic profiling; Southern blot; T-cell receptor sequencing; Western blot.

Publication types

Review

MeSH terms

Animals
Flow Cytometry*
High-Throughput Nucleotide Sequencing*
Humans
Immunohistochemistry*
Immunotherapy*
Neoplasms / diagnosis*
Neoplasms / immunology
Neoplasms / therapy*

Grants and funding

P30 CA045508/CA/NCI NIH HHS/United States