Large Vessel Vasculitis as a Possible Mechanism of Vascular Side Effects of Ponatinib: A Case Report

Klaus Hirschbuehl; Andreas Rank; Tim Pfeiffer; Tina Schaller; Thomas Haeckel; Joerg Roeling; Dmytro Vlasenko; Martin Trepel; Christoph Schmid

doi:10.14740/jh519

Large Vessel Vasculitis as a Possible Mechanism of Vascular Side Effects of Ponatinib: A Case Report

J Hematol. 2019 Jun;8(2):83-85. doi: 10.14740/jh519. Epub 2019 Jun 30.

Authors

Klaus Hirschbuehl¹, Andreas Rank¹, Tim Pfeiffer¹, Tina Schaller², Thomas Haeckel³, Joerg Roeling⁴, Dmytro Vlasenko⁵, Martin Trepel¹, Christoph Schmid¹

Affiliations

¹ Department of Hematology and Oncology, Universitaetsklinikum Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany.
² Institute of Pathology, Universitaetsklinikum Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany.
³ Department of Radiology, Universitaetsklinikum Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany.
⁴ Internistische Gemeinschaftspraxis am Vincentinum, Franziskanergasse 14, 86152 Augsburg, Germany.
⁵ Department of Visceral Surgery, Universitaetsklinikum Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany.

PMID: 32300450
PMCID: PMC7153681
DOI: 10.14740/jh519

Abstract

Arterial occlusive events (AOEs) such as cerebrovascular, cardiovascular and peripheral arterial events are known side effects of ponatinib, assumed due to the rapid development and increase of arteriosclerosis, while the definitive pathomechanisms therefore are still unclear. We present a case of clinically apparent large vessel vasculitis and discuss this phenomenon as a possible mechanism of AOEs beside arteriosclerosis.

Keywords: Arterial occlusive events; Ponatinib; Vasculitis.

Publication types

Case Reports