In this study, the effect of Spathiphyllum blandum on the removal of ibuprofen (IB) and conventional pollutants such as chemical oxygen demand (COD), total nitrogen (TN), ammonium (NH4 +-N), total phosphorus (TP), and total suspended solids (TSS) is reported; this, through its use as an emergent vegetation in fully saturated (FS) constructed wetlands (CWs) at mesocosm level treating polluted river water. With the exception of TP and COD, it was found that for TN (12%), NH4 +-N (11%), TSS (19%), and IB (23%), the removals in systems with vegetation were superior to systems without vegetation (p < 0.05). These findings demonstrate the importance of the species S. blandum, in particular, for the removal of ibuprofen, which is an anti-inflammatory drug commonly found in effluents of wastewater treatment plants. Thus, the results obtained provide information that can be used for the design of future efficient large-scale systems using a new ornamental species, mainly under tropical climatic conditions.