γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Benjamin E Willcox; Fiyaz Mohammed; Carrie R Willcox

doi:10.1016/j.tibs.2020.03.012

γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Trends Biochem Sci. 2020 Jul;45(7):551-553. doi: 10.1016/j.tibs.2020.03.012. Epub 2020 Apr 13.

Authors

Benjamin E Willcox¹, Fiyaz Mohammed², Carrie R Willcox²

Affiliations

¹ Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK. Electronic address: B.Willcox@bham.ac.uk3.
² Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK.

Abstract

Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.

Keywords: T cell receptor (TCR); complementarity determining region (CDR); gamma delta; major histocompatibility complex (MHC).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Histocompatibility Antigens Class I*
Humans
Ligands
Minor Histocompatibility Antigens
Receptors, Antigen, T-Cell, gamma-delta*
T-Lymphocytes / immunology

Substances

Histocompatibility Antigens Class I
Ligands
MR1 protein, human
Minor Histocompatibility Antigens
Receptors, Antigen, T-Cell, gamma-delta