Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy

Robert J Griffin; Mansoor M Ahmed; Beatriz Amendola; Oleg Belyakov; Søren M Bentzen; Karl T Butterworth; Sha Chang; C Norman Coleman; Valentin Djonov; Sylvia C Formenti; Eli Glatstein; Chandan Guha; Shalom Kalnicki; Quynh-Thu Le; Billy W Loo Jr; Anand Mahadevan; Mariangela Massaccesi; Peter G Maxim; Majid Mohiuddin; Mohammed Mohiuddin; Nina A Mayr; Ceferino Obcemea; Kristoffer Petersson; William Regine; Mack Roach; Pantaleo Romanelli; Charles B Simone 2nd; James W Snider; Douglas R Spitz; Bhadrasain Vikram; Marie-Catherine Vozenin; May Abdel-Wahab; James Welsh; Xiaodong Wu; Charles L Limoli

doi:10.1016/j.ijrobp.2020.03.028

Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy

Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):766-778. doi: 10.1016/j.ijrobp.2020.03.028. Epub 2020 Apr 13.

Authors

Robert J Griffin¹, Mansoor M Ahmed², Beatriz Amendola³, Oleg Belyakov⁴, Søren M Bentzen⁵, Karl T Butterworth⁶, Sha Chang⁷, C Norman Coleman², Valentin Djonov⁸, Sylvia C Formenti⁹, Eli Glatstein¹⁰, Chandan Guha¹¹, Shalom Kalnicki¹¹, Quynh-Thu Le¹², Billy W Loo Jr¹², Anand Mahadevan¹³, Mariangela Massaccesi¹⁴, Peter G Maxim¹⁵, Majid Mohiuddin¹⁶, Mohammed Mohiuddin¹⁷, Nina A Mayr¹⁸, Ceferino Obcemea², Kristoffer Petersson¹⁹, William Regine²⁰, Mack Roach²¹, Pantaleo Romanelli²², Charles B Simone 2nd²³, James W Snider²⁰, Douglas R Spitz²⁴, Bhadrasain Vikram², Marie-Catherine Vozenin²⁵, May Abdel-Wahab²⁶, James Welsh²⁷, Xiaodong Wu²⁸, Charles L Limoli²⁹

Affiliations

¹ Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
² Division of Cancer Treatment and Diagnosis, Rockville, Maryland.
³ Innovative Cancer Institute, South Miami, Florida.
⁴ International Atomic Energy Agency, Vienna International Centre, Vienna, Austria.
⁵ Division of Biostatistics and Bioinformatics, University of Maryland, Baltimore, Maryland.
⁶ Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, United Kingdom.
⁷ Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
⁸ Bern Institute of Anatomy, University of Bern, Bern, Switzerland.
⁹ Department of Radiation Oncology, Weill Cornell Medicine, New York, New York.
¹⁰ Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
¹¹ Department of Radiation Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.
¹² Department of Radiation Oncology, Stanford University Medical Center, Stanford, California.
¹³ Department of Radiation Oncology, Geisinger Health Systems, Danville, Pennsylvania.
¹⁴ Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
¹⁵ Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana.
¹⁶ Radiation Oncology Consultants, Park Ridge, Illinois.
¹⁷ Radiation Oncology, Scottsdale, Arizona.
¹⁸ Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington.
¹⁹ Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
²⁰ Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
²¹ Department of Radiation Oncology & Urology, University of California, San Francisco, San Francisco, California.
²² Brain Radiosurgery, Cyberknife Center, CDI, Milan, Italy.
²³ Department of Radiation Oncology, New York Proton Center, New York, New York.
²⁴ Free Radical & Radiation Biology Program, University of Iowa, Iowa City, Iowa.
²⁵ Laboratory of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland.
²⁶ International Atomic Energy Agency Headquarters, Vienna International Centre, Vienna, Austria.
²⁷ Edward Hines VA Medical Center and Loyola University Stritch School of Medicine, Chicago, Illinois.
²⁸ Executive Medical Physics Associates, Miami, Florida; Shanghai Proton and Heavy Ion Center, Shanghai, China.
²⁹ Department of Radiation Oncology, University of California-Irvine, Irvine, California. Electronic address: climoli@uci.edu.

PMID: 32298811
DOI: 10.1016/j.ijrobp.2020.03.028

Abstract

The National Cancer Institute's Radiation Research Program, in collaboration with the Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High Dose Rate and Spatially Fractionated Radiotherapy on August 20 and 21, 2018 to bring together experts in experimental and clinical experience in these and related fields. Critically, the overall aims were to understand the biological underpinning of these emerging techniques and the technical/physical parameters that must be further defined to drive clinical practice through innovative biologically based clinical trials.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Clinical Trials as Topic
Dose Fractionation, Radiation*
Humans
Radiation Dosage*
Radiotherapy / methods*
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding