Boronate ester cross-linked PVA hydrogels for the capture and H2O2-mediated release of active fluorophores

George T Williams; Adam C Sedgwick; Sajal Sen; Lauren Gwynne; Jordan E Gardiner; James T Brewster 2nd; Jennifer R Hiscock; Tony D James; A Toby A Jenkins; Jonathan L Sessler

doi:10.1039/d0cc01904f

Boronate ester cross-linked PVA hydrogels for the capture and H₂O₂-mediated release of active fluorophores

Chem Commun (Camb). 2020 May 21;56(41):5516-5519. doi: 10.1039/d0cc01904f.

Affiliations

¹ Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk a.t.a.jenkins@bath.ac.uk and School of Physical Sciences, University of Kent, Canterbury, CT2 7NH, UK. J.R.Hiscock@kent.ac.uk.
² Department of Chemistry, University of Texas at Austin, 105 E 24th street A5300, Austin, TX 78712-1224, USA. sessler@cm.utexas.edu.
³ Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk a.t.a.jenkins@bath.ac.uk.
⁴ School of Physical Sciences, University of Kent, Canterbury, CT2 7NH, UK. J.R.Hiscock@kent.ac.uk.

Abstract

A new set of PVA hydrogels were formed using the boronate ester fluorescent probe PF1 and the novel boronate fluorescent probe PT1 as the covalent crosslinkers. Treatment with aqueous H2O2 allowed triggered release of the fluorescent dye accompanied by complete dissolution of the hydrogel.

MeSH terms

Boronic Acids / chemistry*
Cross-Linking Reagents / chemical synthesis
Cross-Linking Reagents / chemistry
Esters / chemistry*
Fluorescent Dyes / chemistry*
Hydrogels / chemical synthesis
Hydrogels / chemistry*
Hydrogen Peroxide / chemistry*
Materials Testing
Molecular Structure
Polyvinyl Alcohol / chemical synthesis
Polyvinyl Alcohol / chemistry*
Spectrometry, Fluorescence

Substances

Boronic Acids
Cross-Linking Reagents
Esters
Fluorescent Dyes
Hydrogels
Polyvinyl Alcohol
Hydrogen Peroxide

Grants and funding

R01 GM103790/GM/NIGMS NIH HHS/United States