Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Anu Laulajainen-Hongisto; Sanna Katriina Toppila-Salmi; Annika Luukkainen; Robert Kern

doi:10.3389/fcell.2020.00204

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Front Cell Dev Biol. 2020 Mar 27:8:204. doi: 10.3389/fcell.2020.00204. eCollection 2020.

Authors

Anu Laulajainen-Hongisto^{1

2}, Sanna Katriina Toppila-Salmi^{3

4}, Annika Luukkainen³, Robert Kern⁵

Affiliations

¹ Department of Otorhinolaryngology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
² Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
³ Haartman Institute, Medicum, University of Helsinki, Helsinki, Finland.
⁴ Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
⁵ Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Abstract

Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

Keywords: allergic rhinitis (AR); asthma; chronic rhinosinusitis; epithelium; inflammation.

Publication types

Review