Dental Sealant Empowered by 1,3,5-Tri Acryloyl Hexahydro-1,3,5-Triazine and α-Tricalcium Phosphate for Anti-Caries Application

Juliana Caletti Monteiro; Michele Stürmer; Isadora Martini Garcia; Mary Anne Melo; Salvatore Sauro; Vicente Castelo Branco Leitune; Fabrício Mezzomo Collares

doi:10.3390/polym12040895

Dental Sealant Empowered by 1,3,5-Tri Acryloyl Hexahydro-1,3,5-Triazine and α-Tricalcium Phosphate for Anti-Caries Application

Polymers (Basel). 2020 Apr 12;12(4):895. doi: 10.3390/polym12040895.

Authors

Juliana Caletti Monteiro¹, Michele Stürmer¹, Isadora Martini Garcia¹, Mary Anne Melo^{2

3}, Salvatore Sauro^{4

5}, Vicente Castelo Branco Leitune¹, Fabrício Mezzomo Collares¹

Affiliations

¹ Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, Porto Alegre RS 90035-003, Brazil.
² Ph.D. Program in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
³ Operative Dentistry Division, General Dentistry Department University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
⁴ Departamento de Odontología, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, C/Del Pozo (s/n), Alfara del Patriarca, 46115 Valencia, Spain.
⁵ Department of Therapeutic Dentistry, Sechenov University of Moscow, Mozhaisky Val, 11, Moscow 119435, Russia.

Abstract

: Quaternary ammonium compounds and calcium phosphates have been incorporated into dental materials to enhance their biointeractivity and preventive effects. This study aimed at evaluating the physical and chemical properties and effects against Streptococcus mutans of a dental sealant containing 1,3,5-tri acryloyl hexahydro-1,3,5-triazine (TAT) and α-tricalcium phosphate (α-TCP). A methacrylate-based dental sealant was initially formulated. α-TCP and TAT (G_α-TCPTAT) were added to the experimental sealant at 2 wt.% each. One group was formulated without α-TCP and TAT and used as control (G_CTRL). All tested resins were analyzed for polymerization kinetics and degree of conversion (DC %), Knoop hardness (KHN), softening in solvent (∆KHN%), ultimate tensile strength (UTS), the contact angle with water or with α-bromonaphthalene, surface free energy (SFE) and antibacterial activity against Streptococcus mutans in biofilm and in planktonic cells. The polymerization kinetic was different between groups, but without statistical differences in the DC % (p<0.05). KHN and ΔKHN% did not change between groups (p>0.05), but G_α-TCPTAT presented greater UTS compared to G_CTRL (p<0.05). No differences were found for contact angle (p>0.05) or SFE (p>0.05). G_α-TCPTAT showed greater antibacterial activity in comparison to G_CTRL (p<0.05). The formulation of dental sealants containing TAT and α-TCP can be characterized by improved mechanical and antibacterial properties.

Keywords: antibacterial; dental resin; polymerization; remineralizing; triazines.