Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control

Daria Mordovkina; Dmitry N Lyabin; Egor A Smolin; Ekaterina M Sogorina; Lev P Ovchinnikov; Irina Eliseeva

doi:10.3390/biom10040591

Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control

Biomolecules. 2020 Apr 11;10(4):591. doi: 10.3390/biom10040591.

Authors

Daria Mordovkina¹, Dmitry N Lyabin¹, Egor A Smolin¹, Ekaterina M Sogorina¹, Lev P Ovchinnikov¹, Irina Eliseeva¹

Affiliation

¹ Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.

Abstract

Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed.

Keywords: RNA; Y-box-binding proteins; YB-1; YB-2; YB-3; YBX1; mRNP; stability regulation; translation regulation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytoplasmic Granules / metabolism
Humans
Protein Binding
Protein Biosynthesis / genetics*
RNA Stability / genetics*
Ribonucleoproteins / metabolism*
Y-Box-Binding Protein 1 / chemistry
Y-Box-Binding Protein 1 / metabolism*

Substances

Ribonucleoproteins
Y-Box-Binding Protein 1
messenger ribonucleoprotein

Abstract

Publication types

MeSH terms

Substances

Grants and funding