Comparison of Bioelectrical Impedance Analysis and Dual Energy X-ray Absorptiometry for Total and Segmental Bone Mineral Content with a Three-Compartment Model

Yu-San Liao; Hung-Chou Li; Hsueh-Kuan Lu; Chung-Liang Lai; Yue-Sheng Wang; Kuen-Chang Hsieh

doi:10.3390/ijerph17072595

Comparison of Bioelectrical Impedance Analysis and Dual Energy X-ray Absorptiometry for Total and Segmental Bone Mineral Content with a Three-Compartment Model

Int J Environ Res Public Health. 2020 Apr 10;17(7):2595. doi: 10.3390/ijerph17072595.

Authors

Yu-San Liao^{1

2

3}, Hung-Chou Li⁴, Hsueh-Kuan Lu⁵, Chung-Liang Lai^{6

7}, Yue-Sheng Wang⁸, Kuen-Chang Hsieh⁹

Affiliations

¹ Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Yunlin 638, Taiwan.
² Department of Nursing, Chang Gung University of Science and Technology, Chiayi 613, Taiwan.
³ Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi 621, Taiwan.
⁴ Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
⁵ General Education Center, National Taiwan University of Sport, Taichung 404, Taiwan.
⁶ Department of Physical Medicine and Rehabilitation, Puzi Hospital, Ministry of Health and Welfare, Chiayi 613, Taiwan.
⁷ Department of Occupational Therapy, Asia University, Taichung 413, Taiwan.
⁸ Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi613, Taiwan.
⁹ Fundamental Education Center, National Chin-Yi University of Technology, Taichung 411, Taiwan.

Abstract

Modern bioelectrical impedance analysis (BIA) provides a wide range of body composition estimates such as fat mass (FM), lean body mass (LBM), and body water, using specific algorithms. Assuming that the fat free mass (FFM) and LBM can be accurately estimated by the 8-electrode BIA analyzer (BIA_8MF; InBody230, Biospace), the bone mineral content (BMC) may be calculated by subtracting the LBM from the FFM estimates based on the three-compartment (3C) model. In this cross-sectional study, 239 healthy Taiwanese adults (106 male and 133 female) aged 20-45 years were recruited for BIA and dual-energy X-ray absorptiometry (DXA) measurements of the whole body and body segments, with DXA as the reference. The results showed a high correlation between BIA_8MF and DXA in estimating total and segmental LBM, FM and percentage body fat (r = 0.909-0.986, 0.757-0.964, and 0.837-0.936, respectively). For BMC estimates, moderate to high correlations (r = 0.425-0.829) between the two methods were noted. The percentage errors and pure errors for BMC estimates between the methods ranged from 33.9% to 93.0% and from 0.159 kg to 0.969 kg, respectively. This study validated that BIA_8MF can accurately assesses LBM, FM and body fat percentage (BF%). However, the estimation of segmental BMC based on the difference between FFM and LBM in body segments may not be reliable by BIA_8MF.

Keywords: BIA; DXA; bone mineral content; multi-frequency; segment; three-compartment.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Absorptiometry, Photon*
Adipose Tissue
Adult
Body Composition*
Bone Density / physiology*
Cross-Sectional Studies
Electric Impedance*
Female
Humans
Male
Middle Aged
Taiwan