Autochthonous ST405 NDM-5 producing Escherichia coli causing fatal sepsis in Northern Italy

Anna Maria Peri; Aurora Piazza; Valentina De Zan; Manuela Carugati; Antonio Muscatello; Francesco Comandatore; Elisa De Lorenzis; Mauro Pluderi; Milena Arghittu; Lisa Cariani; Anna Paola Cantù; Claudio Bandi; Massimo Cugno; Andrea Gori; Alessandra Bandera

doi:10.1016/j.ijantimicag.2020.105953

Autochthonous ST405 NDM-5 producing Escherichia coli causing fatal sepsis in Northern Italy

Int J Antimicrob Agents. 2020 May;55(5):105953. doi: 10.1016/j.ijantimicag.2020.105953. Epub 2020 Apr 11.

Authors

Affiliations

¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy. Electronic address: annamaria.peri@policlinico.mi.it.
² Romeo ed Enrica Invernizzi Pediatric Research Center, Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy.
³ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, UOC Medicina Generale - Emostasi e Trombosi, Milan, Italy.
⁴ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy; Division of Infectious Disaeses and International Health, Duke University, Durham, NC, USA.
⁵ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy.
⁶ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Urology, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
⁷ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Neurosurgery Unit, Milan, Italy.
⁸ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Medical Laboratory of Clinical Chemistry and Microbiology, Milan, Italy.
⁹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, Milan, Italy.
¹⁰ Romeo ed Enrica Invernizzi Pediatric Research Center, Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy.
¹¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, UOC Medicina Generale - Emostasi e Trombosi, Milan, Italy; Centre for Multidisciplinary Research in Health Science, Milan, Italy.
¹² Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy; Centre for Multidisciplinary Research in Health Science, Milan, Italy.
¹³ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy; Centre for Multidisciplinary Research in Health Science, Milan, Italy.

PMID: 32289435
DOI: 10.1016/j.ijantimicag.2020.105953

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged
Anti-Bacterial Agents
Carbapenem-Resistant Enterobacteriaceae / drug effects
Carbapenem-Resistant Enterobacteriaceae / genetics
Carbapenem-Resistant Enterobacteriaceae / isolation & purification*
Escherichia coli / drug effects
Escherichia coli / genetics*
Escherichia coli / metabolism
Escherichia coli Infections / drug therapy
Escherichia coli Infections / mortality*
Genome, Bacterial / genetics
Humans
Italy
Male
Microbial Sensitivity Tests
Sepsis / microbiology
Sepsis / mortality*
beta-Lactamases / biosynthesis
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
beta lactamase NDM-5, E coli
beta-Lactamases