Graphical representation methods: How well do they discriminate between homologous gene sequences?

Dwaipayan Sen; Proyasha Roy; Ashesh Nandy; Subhash C Basak; Sukhen Das

doi:10.1016/j.chemphys.2018.07.031

Graphical representation methods: How well do they discriminate between homologous gene sequences?

Chem Phys. 2018 Sep 24:513:156-164. doi: 10.1016/j.chemphys.2018.07.031. Epub 2018 Jul 26.

Authors

Dwaipayan Sen¹, Proyasha Roy¹, Ashesh Nandy¹, Subhash C Basak², Sukhen Das³

Affiliations

¹ Centre for Interdisciplinary Research and Education, Jodhpur Park, Kolkata 700068, India.
² Department of Chemistry & Biochemistry, University of Minnesota Duluth, 5013 Miller Trunk Highway, Duluth, MN 55811, USA.
³ Physics Department, Jadavpur University, Jadavpur, Kolkata 700032, India.

Abstract

Graphical representation methods constitute a class of alignment-free techniques for comparative study of biomolecular sequences. In this brief commentary, we study how well some of these methods can discriminate among closely related genes.

Keywords: 2D and 3D methods; Discriminatory power of sequence descriptors; Flavivirus envelope genes; Globin genes; Graphical representation; Super-descriptors.