Critical overview on the application of sensors and biosensors for clinical analysis

Celine I L Justino; Armando C Duarte; Teresa A P Rocha-Santos

doi:10.1016/j.trac.2016.04.004

Critical overview on the application of sensors and biosensors for clinical analysis

Trends Analyt Chem. 2016 Dec:85:36-60. doi: 10.1016/j.trac.2016.04.004. Epub 2016 Apr 8.

Authors

Celine I L Justino^{1

2}, Armando C Duarte¹, Teresa A P Rocha-Santos¹

Affiliations

¹ Department of Chemistry & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
² ISEIT/Viseu, Instituto Piaget, Estrada do Alto do Gaio, Galifonge, 3515-776 Lordosa, Viseu, Portugal.

Abstract

Sensors and biosensors have been increasingly used for clinical analysis due to their miniaturization and portability, allowing the construction of diagnostic devices for point-of-care testing. This paper presents an up-to-date overview and comparison of the analytical performance of sensors and biosensors recently used in clinical analysis. This includes cancer and cardiac biomarkers, hormones, biomolecules, neurotransmitters, bacteria, virus and cancer cells, along with related significant advances since 2011. Some methods of enhancing the analytical performance of sensors and biosensors through their figures of merit are also discussed.

Keywords: Analytical performance; Biosensor; Clinical analysis; Figure of merit; Sensor.

Publication types

Review