Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis

Grzegorz Mlostoń; Emilia Obijalska; Heinz Heimgartner

doi:10.1016/j.jfluchem.2010.05.014

Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis

J Fluor Chem. 2010 Aug;131(8):829-843. doi: 10.1016/j.jfluchem.2010.05.014. Epub 2010 Jun 4.

Authors

Grzegorz Mlostoń¹, Emilia Obijalska¹, Heinz Heimgartner²

Affiliations

¹ Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, PL-91-403, Łódź, Poland.
² Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

Abstract

A comprehensive overview on methods applied for syntheses of β-amino-α-trifluoromethyl alcohols, including stereocontrolled variants, is presented. In addition, reported cases of the exploration of β-amino-α-trifluoromethyl alcohols for the preparation of trifluoromethylated peptidomimetics and other biologically active, fluorinated compounds are discussed. Attractive opportunities for their applications as organocatalysts are also presented.

Keywords: Amino alcohols; Biological activity; Fluorinated compounds; Organic synthesis; Stereocontrolled processes; Trifluoromethyl alcohols.

Publication types

Review