CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection

AIDS. 2020 Jul 1;34(8):1249-1252. doi: 10.1097/QAD.0000000000002544.

Abstract

: Human CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4 T cells from HIV-1-infected patients. We found that infected CD4+RA- T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4 T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / metabolism*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • HIV Infections / diagnosis*
  • HIV Infections / immunology
  • HIV-1*
  • Humans
  • Immunologic Memory
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / metabolism*

Substances

  • Antigens, CD
  • CD300A protein, human
  • Receptors, Immunologic