Pneumopericardium is a potential complication to frequent cannabis smoking due to barotrauma of the airways caused by forceful coughing and Valsalva's manoeuvre. This is a case report of a 27-year-old man, who had a daily consumption of cannabis and presented with abdominal pain and nausea consistent with cannabinoid hyperemesis syndrome. A CT scan revealed an asymptomatic isolated minor pneumopericardium. The patient was observed, and no intervention was needed. At an outpatient control ten days later the pneumopericardium had spontaneously resolved.