Study of Indicators for Early and Rapid Diagnosis of Radiation Injury Is the Most Important in Patients With Cancer During Radiotherapy

Gang Liu; Li-Mei Niu; Li-Qin Wang; Ye Li; Xiao-Qin Wu; Yin-Yin Liu; Rong Zhang

doi:10.1177/1559325820913360

Study of Indicators for Early and Rapid Diagnosis of Radiation Injury Is the Most Important in Patients With Cancer During Radiotherapy

Dose Response. 2020 Mar 30;18(1):1559325820913360. doi: 10.1177/1559325820913360. eCollection 2020 Jan-Mar.

Authors

Gang Liu¹, Li-Mei Niu¹, Li-Qin Wang¹, Ye Li¹, Xiao-Qin Wu¹, Yin-Yin Liu¹, Rong Zhang¹

Affiliation

¹ Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China.

Abstract

Objective: To establish a complete technical solution for the radiation biological dose estimation, to enable prediction of individuals' response to radiotherapy (RT), and to control treatment dose for reduced irradiation injury and promote repair; and to evaluate the risk of radiation-induced late effects for patients undergoing external photon beam RT and provide the reliable dose-response relationships.

Methods: Select 49 tumor patients using ⁶⁰Co and linear accelerator for radiation therapy; initial radiation dose was 250 cGy. Chromosome aberration and blood count were analyzed before radiation therapy and 2 hours after the first day of RT.

Results: Two hours after the first day of RT, peripheral blood cell count of lymphocytes of patients with cancer was significantly decreased (P < .01). The frequency of chromosome aberration was higher (P < .01).

Conclusion: High-dose radiation of the radiation therapy makes significant injuries to peripheral blood lymphocytes.

Keywords: dicentric chromosome analysis; first irradiating; peripheral blood lymphocytes; radiation injuries.