Nonylphenol induced individual and population fluctuation of Caenorhabditis elegans: Disturbances on developmental and reproductive system

Xue Cao; Chenzhi Yan; Xuan Wu; Lei Zhou; Guangli Xiu

doi:10.1016/j.envres.2020.109486

Nonylphenol induced individual and population fluctuation of Caenorhabditis elegans: Disturbances on developmental and reproductive system

Environ Res. 2020 Jul:186:109486. doi: 10.1016/j.envres.2020.109486. Epub 2020 Apr 8.

Authors

Xue Cao¹, Chenzhi Yan¹, Xuan Wu¹, Lei Zhou², Guangli Xiu³

Affiliations

¹ State Environmental Protection Key Lab of Environmental Risk Assessment and Control on Chemical Processes, School of Resources & Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China; Shanghai Environmental Protection Key Laboratory for Environmental Standard and Risk Management of Chemical Pollutants, School of Resources & Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China.
² State Environmental Protection Key Lab of Environmental Risk Assessment and Control on Chemical Processes, School of Resources & Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China; Shanghai Environmental Protection Key Laboratory for Environmental Standard and Risk Management of Chemical Pollutants, School of Resources & Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China. Electronic address: zhoulei@ecust.edu.cn.
³ State Environmental Protection Key Lab of Environmental Risk Assessment and Control on Chemical Processes, School of Resources & Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China; Shanghai Environmental Protection Key Laboratory for Environmental Standard and Risk Management of Chemical Pollutants, School of Resources & Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China. Electronic address: xiugl@ecust.edu.cn.

PMID: 32283338
DOI: 10.1016/j.envres.2020.109486

Abstract

The environmental risks that have arisen from endocrine disruption compounds (EDCs) have become global challenges, especially for persistent bio-accumulated xenobiotic chemicals, such as nonylphenol (NP). In the present study, the population dynamics of Caenorhabditis elegans (C. elegans) were systemically investigated by conducting developmental and reproductive bioassays under the exposure of NP, which has been widely detected in actual aquatic environments. The results revealed that under NP exposure (400 μg L^-1 NP), developmental indictors of C. elegans, including the body length and width were significantly inhibited at different life stages of L1 and L4 larva, and the growth curves were further adversely affected. In addition, abnormalities in reproductive systems were also observed under NP exposure. Such abnormalities obeyed a dose-dependent relationship with NP levels, which were closely related to the delayed spawning time and decreased reproductive rates. Moreover, the results from global genome expression analysis for nematodes revealed that the most significant enriched GO terms could be predominantly responsible for the dysregulation of growth and reproductive system. The population's parameters, including age composition and intrinsic growth rate (r_m d^-1), displayed significant changes, with a suppressed potentiality of population growth. Those data elucidated that NP exhibited a profound impact on the dynamic stability of the population, even with no obvious effect on certain biochemical markers.

Keywords: Caenorhabditis elegans; Development; Nonylphenol; Population homeostasis; Reproductive system.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Caenorhabditis elegans* / genetics
Genitalia
Phenols* / toxicity
Reproduction

Substances

Phenols
nonylphenol

Grants and funding

P40 OD010440/OD/NIH HHS/United States