Abstract
Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus Brasilomena, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol (2) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only 2 reduced in vitro thromboxane B2 and superoxide anion (O2-) generation from Escherichia coli lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cyanobacteria / chemistry*
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Diterpenes / chemistry*
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Ear Diseases / drug therapy*
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Edema
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Escherichia coli / chemistry*
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Lipopolysaccharides / chemistry*
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Mice
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Rats
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Superoxides / chemistry*
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Thromboxane B2 / chemistry*
Substances
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Anti-Inflammatory Agents
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Diterpenes
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Lipopolysaccharides
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tolypodiol
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Superoxides
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Thromboxane B2