Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Matthew S Dietz; Catherine Z Beach; Ramon Barajas; Michael S Parappilly; Sidharth K Sengupta; Lissa C Baird; Jeremy N Ciporen; Seunggu J Han; Rebecca Loret de Mola; Yoon Jae Cho; Kellie J Nazemi; Shearwood McClelland 3rd; Melissa H Wong; Jerry J Jaboin

doi:10.1016/j.adro.2019.12.008

Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Adv Radiat Oncol. 2020 Jan 28;5(2):152-162. doi: 10.1016/j.adro.2019.12.008. eCollection 2020 Mar-Apr.

Authors

Matthew S Dietz¹, Catherine Z Beach², Ramon Barajas^{3

4}, Michael S Parappilly³, Sidharth K Sengupta⁵, Lissa C Baird⁶, Jeremy N Ciporen⁶, Seunggu J Han⁶, Rebecca Loret de Mola¹, Yoon Jae Cho^{7

8}, Kellie J Nazemi¹, Shearwood McClelland 3rd⁹, Melissa H Wong^{5

8}, Jerry J Jaboin^{2

8}

Affiliations

¹ Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.
² Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon.
³ Department of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon.
⁴ Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon.
⁵ Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon.
⁶ Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon.
⁷ Department of Neurology, Oregon Health & Science University, Portland, Oregon.
⁸ The Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
⁹ Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana.

Abstract

Purpose: To review and critique the current state of liquid biopsy in pHGG.

Materials and methods: Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas.

Results: This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development.

Conclusions: While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development.

Publication types

Review

Grants and funding

TL1 TR002371/TR/NCATS NIH HHS/United States