LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16

Xiaoqiong Tang; Yaoying Long; Liuyue Xu; Xinyu Yan

doi:10.2147/CMAR.S233859

LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16

Cancer Manag Res. 2020 Mar 23:12:2119-2125. doi: 10.2147/CMAR.S233859. eCollection 2020.

Authors

Xiaoqiong Tang¹, Yaoying Long¹, Liuyue Xu¹, Xinyu Yan¹

Affiliation

¹ Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing City 400016, People's Republic of China.

Abstract

Introduction: LncRNA mortal obligate RNA transcript (MORT) is downregulated in different types of cancer, indicating its involvement in cancer biology.

Methods: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. The low levels of MORT and miRNA-16 were correlated with poor survival of MCL patients. The expression of MORT and miRNA-16 was positively correlated only in MCL patients.

Results: Overexpression of MORT and miRNA-16 suppressed cell proliferation but promoted cancer cell apoptosis, while miRNA-16 inhibitor reduced the effects of MORT overexpression. Overexpression of MORT led to upregulated expression of miRNA-16, while overexpression of miRNA-16 had no effect on the expression of MORT.

Conclusion: Therefore, MORT may inhibit cancer cell proliferation and promote apoptosis in mantle cell lymphoma by upregulating miRNA-16.

Keywords: MORT; cancer cell; mantle cell lymphoma; miRNA-16; prognosis.