Fibrocalculous Pancreatic Diabetes

Curr Diab Rep. 2020 Apr 11;20(6):19. doi: 10.1007/s11892-020-01303-1.

Abstract

Purpose of review: Fibrocalculous pancreatic diabetes (FCPD) is an uncommon form of diabetes occurring in underprivileged developing countries of the world. We attempt to review the latest evidence on epidemiology, secular trends, etiopathogenic mechanisms, and treatment modalities of FCPD with particular reference to studies from the past decade.

Recent findings: There has been little new data on FCPD over the past decade even from countries where it was considered to be prevalent. There appears to be a decline in prevalence of the condition of late. There is also some evidence to show that the condition develops due to as yet unknown environmental influences acting on a background of genetic susceptibility. FCPD is a severe form of diabetes and may be a premalignant condition. FCPD deserves more attention than it currently receives, because of its unique clinical features and management strategies, and its propensity to develop pancreatic adenocarcinoma.

Keywords: Adenocarcinoma; Diabetes; FCPD; Pancreas; TCP.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / etiology*
  • Calcinosis / etiology
  • Developing Countries
  • Diabetes Mellitus / diagnosis*
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / therapy
  • Fibrosis / etiology
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Humans
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / etiology*
  • Pancreatitis, Chronic / diagnosis*
  • Pancreatitis, Chronic / epidemiology
  • Pancreatitis, Chronic / etiology
  • Pancreatitis, Chronic / therapy
  • Precancerous Conditions / diagnosis
  • Precancerous Conditions / etiology*
  • Prevalence
  • Tropical Climate