Halting coronavirus polymerase

J Biol Chem. 2020 Apr 10;295(15):4780-4781. doi: 10.1074/jbc.H120.013397.

Abstract

The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives*
  • Adenosine Monophosphate / pharmacology
  • Alanine / analogs & derivatives*
  • Alanine / pharmacology
  • Animals
  • Antiviral Agents / pharmacology*
  • Coronavirus / drug effects*
  • Coronavirus / enzymology*
  • Coronavirus / physiology
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / virology
  • Exonucleases
  • Humans
  • Pandemics
  • RNA-Dependent RNA Polymerase / antagonists & inhibitors*
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • remdesivir
  • Adenosine Monophosphate
  • RNA-Dependent RNA Polymerase
  • Exonucleases
  • Alanine