Quality, quantity and hematological disorders in blood under Ethanol analyte an in vitro study

Pak J Pharm Sci. 2020 Mar;33(2):561-566.

Abstract

The purpose of this manuscript is to analyze the quantity, quality and disorders of blood components and blood parameters before and after addition of five different concentrations i.e. (0μl, 10μl, 20μl, 30μl and 40μl) of ethyl alcohol (ethanol) in the blood of Brest cancer patient. We diagnose the disorders in cells count, shape of cells, size of cells and many blood parameters like Hemoglobin, Red blood cells distribution width, Mean corpuscular volume, Platelet crit, Mean platelet volume, Platelet distribution width, Hematocrit, Serum glutamic pyruvic transaminase, Cholesterol, Low-density lipoprotein, triglycerides, Serum glutamic oxaloacetic transaminase, high-density lipoprotein, Urea and Total Billirubin by using hematological techniques. We have noted that the number of WBCs and RBCs decrease sharply while platelet cells increases gradually. We also have revealed the shape changes like WBCs show disintegration around RBCs and clumping of Platelet cells. This work will be extended towards the three dimensional imaging using Optical Coherence Tomography (OCT) for monitoring the level of Ethanol in blood via vasculature maps both for the normal and breast cancer.

MeSH terms

  • Blood Cells / drug effects*
  • Blood Cells / metabolism*
  • Breast Neoplasms / blood*
  • Dose-Response Relationship, Drug
  • Erythrocyte Count / methods
  • Ethanol / chemistry
  • Ethanol / pharmacology*
  • Female
  • Hematologic Diseases / blood*
  • Humans
  • Leukocyte Count / methods
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Platelet Count / methods

Substances

  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Ethanol