Abstract
Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role in cardiovascular diseases. Notably, in atherosclerosis, the activation of TRPV1 can regulate lipid metabolism, reduce foam cell formation, protect endothelial cells, inhibit smooth muscle cell proliferation and inhibit inflammation and oxidation. In this review, the role of the TRPV1 channel in atherosclerosis was discussed to provide new ideas for the prevention and treatment of atherosclerotic diseases.
Keywords:
Transient receptor potential vanilloid subfamily member 1 (TRPV1); atherosclerosis; calcitonin gene-related peptide (CGRP); cardiovascular diseases; neuropeptides.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Atherosclerosis / genetics
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Atherosclerosis / metabolism*
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Cardiovascular Diseases / genetics
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Cardiovascular Diseases / metabolism
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Humans
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Lipid Metabolism / genetics
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Lipid Metabolism / physiology
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Neuropeptides / genetics
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Neuropeptides / metabolism
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TRPV Cation Channels / genetics
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TRPV Cation Channels / metabolism*
Substances
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Neuropeptides
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TRPV Cation Channels
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TRPV1 receptor
Grants and funding
This study was supported by the National Natural Science Foundation of China under [Grant No. 81670447]; the National Natural Science Foundation of Zhejiang Province under [Grant No. LY15H020006]; Zhejiang Province Key Subject of Medicine (Neurological Rehabilitation) and the Traditional Chinese Medicine Program of Zhejiang Provincial under [Grant No. 2017ZZ001]; the Zhejiang Provincial Health Commission Project under [Grant No. 2017KY559] Li-hong Wang is sponsored by Zhejiang Provincial Pr gram for the Cultivation of High-Level Innovative Health Talents.