Polycystins, ADPKD, and Cardiovascular Disease

Ivana Y Kuo; Arlene B Chapman

doi:10.1016/j.ekir.2019.12.007

Polycystins, ADPKD, and Cardiovascular Disease

Kidney Int Rep. 2019 Dec 21;5(4):396-406. doi: 10.1016/j.ekir.2019.12.007. eCollection 2020 Apr.

Authors

Ivana Y Kuo¹, Arlene B Chapman²

Affiliations

¹ Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, Illinois, USA.
² Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.

Abstract

Cardiovascular disorders are the most common cause of mortality in autosomal dominant polycystic kidney disease (ADPKD). This review considers recent clinical and basic science studies that address the contributing factors of cardiovascular dysfunction in ADPKD. In particular, attention is placed on how dysfunction of the polycystin proteins located in the cardiovascular system contributes to extrarenal manifestations of ADPKD.

Keywords: calcium signaling; cardiovascular dysfunction; heart failure; polycystic kidney disease.

Publication types

Review