Personalized Medicine in Infertile Men

Urol Clin North Am. 2020 May;47(2):245-255. doi: 10.1016/j.ucl.2019.12.011. Epub 2020 Mar 9.

Abstract

Personalized medicine gathers the most relevant data involved in human health. Currently, the diagnosis of male infertility is limited to spermiogram, which does not provide information on the male fertile potential. New diagnostic methods are required. The application of omics techniques in the study of male reproductive health renders a huge amount of data providing numerous novel infertility biomarkers, from genes to metabolites, to diagnose the cause of male infertility. Recent studies hold the promise that these biomarkers will allow a noninvasive infertility diagnosis and the improvement of the sperm selection techniques.

Keywords: Male infertility; Molecular biomarkers; OMICS; Personalized medicine; Sperm.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Genomics
  • Humans
  • Infertility, Male / diagnosis
  • Infertility, Male / etiology*
  • Infertility, Male / therapy*
  • Male
  • Metabolomics
  • Precision Medicine* / trends
  • Spermatogenesis / physiology

Substances

  • Biomarkers