Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology

Curr Opin Cell Biol. 2020 Apr:63:194-203. doi: 10.1016/j.ceb.2020.03.002. Epub 2020 Apr 6.

Abstract

Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Biology
  • Cell Physiological Phenomena* / genetics
  • Humans
  • Immunity, Innate / genetics
  • Immunity, Innate / physiology*
  • Inflammation / genetics
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Macromolecular Substances / metabolism*
  • Organelles / metabolism*
  • Organelles / physiology
  • Protein Binding
  • Protein Multimerization / physiology*
  • Signal Transduction / genetics
  • Signal Transduction / physiology

Substances

  • Macromolecular Substances