The role of magnesium in biomaterials related infections

Colloids Surf B Biointerfaces. 2020 Jul:191:110996. doi: 10.1016/j.colsurfb.2020.110996. Epub 2020 Mar 29.

Abstract

Magnesium is currently increasing interest in the field of biomaterials. An extensive bibliography on this material in the last two decades arises from its potential for the development of biodegradable implants. In addition, many researches, motivated by this progress, have analyzed the performance of magnesium in both in vitro and in vivo assays with gram-positive and gram-negative bacteria in a very broad range of conditions. This review explores the extensive literature in recent years on magnesium in biomaterials-related infections, and discusses the mechanisms of the Mg action on bacteria, as well as the competition of Mg2+ and/or synergy with other divalent cations in this subject.

Keywords: bacteria; biomaterial; infection; magnesium.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Magnesium / chemistry
  • Magnesium / pharmacology*
  • Microbial Sensitivity Tests
  • Optical Imaging
  • Particle Size
  • Surface Properties

Substances

  • Anti-Bacterial Agents
  • Magnesium