Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference

Hitten P Zaveri; Björn Schelter; Catherine A Schevon; Premysl Jiruska; John G R Jefferys; Gregory Worrell; Andreas Schulze-Bonhage; Rasesh B Joshi; Viktor Jirsa; Marc Goodfellow; Christian Meisel; Klaus Lehnertz

doi:10.1016/j.seizure.2020.03.010

Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference

Seizure. 2020 May:78:78-85. doi: 10.1016/j.seizure.2020.03.010. Epub 2020 Mar 19.

Authors

Affiliations

¹ Department of Neurology, Yale University, New Haven, CT 06520, USA.
² Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen AB24 3UE, UK.
³ Department of Neurology, Columbia University, New York, NY, USA.
⁴ Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
⁵ Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
⁶ Mayo Systems Electrophysiology Laboratory, Departments of Neurology and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
⁷ Epilepsy Center, University Medical Center Freiburg, Freiburg, Germany.
⁸ Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁹ Institut de Neurosciences des Systèmes, Aix Marseille University, Marseille, France.
¹⁰ Living Systems Institute, University of Exeter, Exeter, UK; Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Exeter, Exeter, UK; EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK.
¹¹ Department of Neurology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA; Department of Neurology, University Clinic Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
¹² Department of Epileptology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany; Interdisciplinary Center for Complex Systems, University of Bonn, Brühler Str. 7, 53175 Bonn, Germany. Electronic address: Klaus.Lehnertz@ukbonn.de.

Abstract

Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.

Keywords: Edges; Epileptic network; Epileptogenesis; Ictogenesis; Nodes; Seizure control.

Publication types

Review

MeSH terms

Congresses as Topic
Epilepsy / diagnosis
Epilepsy / drug therapy
Epilepsy / physiopathology*
Humans
Nerve Net / drug effects
Nerve Net / physiopathology*

Abstract

Publication types

MeSH terms

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